An excess accumulation of fluoride in the body can lead to demineralization of bone and tooth enamel, to a toxic condition called fluorosis. Bony changes, characterized by osteosclerosis, exostoses of the spine, and genu valgum, usually are seen only after prolonged high intake of fluoride in adults. These changes occur due to the fact that fluoride is not biodegradable and it accumulates in the body and bones resulting in a toxic or poisoning effect.
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