Reduce 15 MG Slimming ++ Fastest Slimming & Top Hit Products.

You will receive 500 pills (50 Pack) 5 Boxes


Composition

Each capsules of Reduce 15mg contains

Sibutramine 15mg

Product Description

SIBUTRAMINE belong to the category of appetite suppressant.

The Structural Formula:

1-(4-chlorophenyl)-N,N-dimethyl-a-(2-methylpropyl)-cyclobutanemethanamine

Molecular Formula:C17H26ClN

Molecular Weight:279.85 g/mol

Mechanism Of Action

Inhibits reuptake of norepinephrine, serotonin, and dopamine. May stimulate satiety center in brain, causing appetite suppression. Inhibits reuptake of Serotonin(5.H.T) nor adrenaline and to a lesser extent, dopamine in Vivo and in vitro M1 and M2 Metabolite are pharmacologically active and are up to about 100-fold more potent reuptake inhibitors than sibutramine has no effects on dopamine receptors, some thermogenic activity is evident at doses of 10mg apparent low abuse potential in humans.Reduce (Sibutramine) produce its therapeutic effect by Norepinephrine, Serotonin and dopamine reuptake inhibition.

Pharmaco Kinetics

Reduce reaches maximum therapeutic concentration in 1.2hrs. Food delays the absorption by 3hrs. Approximately 77% of the single oral dose is absorbed. Steady state reached with in 4days. Reduce (Sibutramine) is extensively bound and is rapidly and extensively distributed into tissue. It undergoes extensive first pas metabolism and is primarily by cytochromep4503A4 isoenzyme. Approximately 85% of the drug eliminated through urine.

Indications

Management of obesity, including weight loss and maintenance of weight loss and should be used in conjugation with a reduced calorie diet. Contra Indications

Pregnancy and paediatric patients, hypersensitivity,patients receiving MAO inhibitors,anorexia,nervosa, patients taking other centrally acting appetite suppressant.

Adverse Effects

Dry mouth,anorexia, constipation,insomnia, dizziness.

Special Precautions

Monitor BP regularly when prescribing sibutramine.

Dosage

Its recommended for obese patients with an initial BMI 30kg/m2 or 27kg/m2 in the presence of the risk factors(e.g. hypertension,diabetes,dyslipidemia).Initially 10mg of sibutramine is given once daily with or without food. If there is inadequate weight loss, the dose may be titrated after four weeks to a total of 15mg once daily.





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SHIPPING
I only shipped to PAYPAL confirmed address. Items are despatch within 1-2 days after payment has cleared. The shipping via Airmail register post of Thailand Post. The package will arrive with in 7-25 days.